Agriculture is the leading industry in Yuma County producing over $2.5 billion a year, making Yuma County the Winter Vegetable Capital of the World. Yuma County's success in agriculture is largely due to its climate, rich soil, and skilled workforce.

The United States Government is the top employer in Yuma County, AZ with Marine Air Corp Station Yuma and the Yuma Proving Grounds being the number 1 and 2 employers within the county. The U.S. Army John F. Kennedy Special Warfare Center and School opened in 2014 in Yuma, AZ and is the largest facility of its kind in the world. The facility trains troops for air operations requiring free falling from air crafts.

Tourism is the third largest contributor to the Yuma County's economy. Within close proximity to Mexico, tourists spend an estimated $2.2 billion a year on entertainment, food, and clothing within Yuma County. During winter months, the county doubles in size with Winter Visitors temporarily relocating to the city from Northern United States and Canada. Yuma County's close proximity to Southern California and Mexico make it desirable for site selectors and company executives when relocating businesses. Yuma County's location gives companies an advantage of doing business in Southern California without “being in” Southern California.